What is organ transplantation?
Organ transplantation is where a person is in need of a new organ as a result of organ failure which may be innate or developed, and structural abnormality resulting in change of function. It involves a damaged organ being replaced by another organ from different person.
Organs and tissue that can be transplanted include;
Liver
Kidney
Pancreas
Heart
Lung
Intestine
Cornea
Middle ear
Skin
Bone
Bone marrow
Heart valve
Connective tissue
To be capable of donating or receiving an organ a series of tests must take place prior to the operation to see if their tissue type is a similar match. Tissue type is the term given to seeing if donor and patient have similar proteins and MCH class receptors. The similarity of the MCH class markers determines whether or not an organ will be accepted.
MHC class markers determine whether or not a cell is self or non-self. There is two groups of MHC class markers; class one is non-specific and is found on majority of cells. Class two is specific for T and B cells, and some macrophages. These markers allow Th cells to single-out non-self cells, triggering B Cells and Tc Cells which attempt to kill the foreign antigen.
Organs and tissue that can be transplanted include;
Liver
Kidney
Pancreas
Heart
Lung
Intestine
Cornea
Middle ear
Skin
Bone
Bone marrow
Heart valve
Connective tissue
To be capable of donating or receiving an organ a series of tests must take place prior to the operation to see if their tissue type is a similar match. Tissue type is the term given to seeing if donor and patient have similar proteins and MCH class receptors. The similarity of the MCH class markers determines whether or not an organ will be accepted.
MHC class markers determine whether or not a cell is self or non-self. There is two groups of MHC class markers; class one is non-specific and is found on majority of cells. Class two is specific for T and B cells, and some macrophages. These markers allow Th cells to single-out non-self cells, triggering B Cells and Tc Cells which attempt to kill the foreign antigen.